Is intestinal gluconeogenesis a key factor in the early changes in glucose homeostasis following gastric bypass?

Authors

Mark T. Hayes
Jonathan Foo
Vinko Besic
Yulia Tychinskaya
Richard S. Stubbs

Year of Publication

2011

Source

Obesity Surgery, 21 (6), 759-762

Abstract

This study aimed to examine the hypothesis that under fasting conditions, intestinal gluconeogenesis generates glucose levels in the portal vein which trigger the portal sensor to change insulin resistance and that this mechanism contributes to the effects of Roux-en-Y gastric bypass surgery on type 2 diabetes mellitus. The researchers simultaneously sampled fasting portal venous blood and central venous blood in 28 patients (eight diabetics and 20 non-diabetics) before and again six days after Roux-en-Y gastric bypass surgery in morbidly obese patients, for measurement of glucose levels. They found no significant difference in the glucose levels from the two sites either before or after Roux-en-Y gastric bypass in diabetic patients and a small, but significant difference in the post-operative glucose levels from non-diabetic patients.

Type of Study

Analysis

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