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Men and women respond differently to rapid weight loss: Metabolic outcomes of a multi‐centre intervention study after a low‐energy diet in 2500 overweight, individuals with pre‐diabetes (PREVIEW)

NZ Research Abstract

posted by WM Admin on 15 August 2018


Pia Christensen
Thomas M. Larsen
Margriet Westerterp-Plantenga
Ian Macdonald
J. Alfredo Martinez
Svetoslav Handjiev
Sally D. Poppitt
Sylvia Hansen
Christian Ritz
Arne Astrup
Laura Pastor-Sanz
Finn Sandø‐Pedersen
Kirsi H. Pietiläinen
Jouko Sundvall
Mathijs Drummen
Moira Taylor
Santiago Navas-Carretero
Teodora Handjieva-Darlenska
Shannon Brodie
Marta P. Silvestre
Maija Huttunen‐Lenz
Jennie Brand-Miller
Mikael Fogelholm
Anne Raben

Year of Publication



Diabetes, Obesity and Metabolism, 7 August [Epub before print]

Publication Type

Journal article (peer reviewed)

Publication Status



The authors explored whether the initial, fixed low‐energy diet (LED) would induce different metabolic outcomes in men vs women. Participants from eight sites in Europe, Australia and New Zealand followed a LED for 8 weeks (Cambridge Weight Plan). Those eligible for inclusion were overweight and with pre‐diabetes. 2224 adults attended the baseline visit and 90.8% completed the follow‐up visit. The authors conclude from their analysis that the 8‐week LED induced different effects in women than in men, suggesting gender‐specific changes after weight loss. They go on to say that it "... is important to investigate whether the greater decreases in FFM, hip circumference and HDL cholesterol in women after rapid weight loss compromise weight loss maintenance and future cardiovascular health".

Type of Study

Quantitative, Multicentre

How to Access

This is an open access article and can be read in free full text at:


PREVIEW: NZ (PREVention of diabetes through lifestyle Intervention in NEW Zealand and around the world)