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Evaluation of the diet wide contribution to serum urate levels: Meta-analysis of population based cohorts

NZ Research Abstract

posted by Research Admin on 15 October 2018


Tanya J. Major
Ruth Topless
Nicola Dalbeth
Tony R. Merriman

Year of Publication



BMJ, 363: k3951

Publication Type

Journal article (peer reviewed)

Publication Status



The authors tested dietary components for association with serum urate levels and to evaluate the relative contributions of diet and inherited genetic variants in serum urate levels. Hyperuricaemia (elevated serum urate concentration) is a central risk factor for gout, and is also associated with chronic kidney disease, hypertension, and metabolic syndrome. The authors state that "our results challenge widely held community perceptions that hyperuricaemia is primarily caused by diet, showing that genetic variants have a much greater contribution to hyperuricaemia in the general population than dietary exposure."

Type of Study


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